Valine

Emil Fischer has isolated Valine from casein back in 1901, which was achieved by hydrolyzing proteins. Today Valine is recognized as the branched-chain essential amino acid providing a stimulant activity. Actually, three branched-chain amino acids constitute over 2/3 of the amino acids in the body proteins, pointing out that its role for humans is invaluable.

Chemical Structure
Structure of L-Valine

IUPAC Name: (2S)-2-Amino-3-methylbutanoic acid
Symbol: Three-letter code - Val. One-letter code - V
Molecular Weight (Molar Mass): 117.14634 g/mol
Molecular Formula (Structural Formula): C5H11NO2
Canonical SMILES: CC(C)C(C(=O)O)N
Isomeric SMILES: CC(C)[C@@H](C(=O)O)N
InChIKey Identifier: RVEPXRXYSLTFTD-UHFFFAOYAI
CAS Number: 72-18-4
MDL Number: MFCD00064220
Melting point: 315 °C
Solubility in water: 85 g/1 L (20 °C); pKa - 2,32; pKb - 9,62
2D Molfile: Get the molfile
3D PDB file: Get the PDB file
Other names: L-2-Amino-3-methylbutyric acid; (S)-α-Aminoisovaleric acid; L-alpha-Aminoisovaleric acid


This amino acid aids preventing the breakdown of muscle, because it supplies the muscles with an extra glucose responsible for the energy production during physical activity. Valine is also a precursor in the penicillin biosynthetic pathway and is known for inhibiting the transport of Tryptophan across the blood-brain barrier.

In other words, Valine is an essential amino acid important for smooth nervous system and cognitive functioning. Valine is one of the three branched-chain amino acids, along with Leucine and Isoleucine. This amino acid cannot be produced by your body and must be obtained through food or through supplements. Valine is important for everyday body functions and for maintaining muscles, as well as for the regulation of the immune system. This particular amino acid is not processed by the liver, but is taken up by muscles. You can obtain it through kidney beans, leafy vegetables, poultry and milk.

Valine provides numerous benefits like improvement in insomnia and nervousness. Besides, it is also proved to help alleviate disorders of the muscles, and to be an effective appetite suppressant. This amino acid also greatly improves the regulation of the immune system, but probably the greatest benefits of Valine are experienced by athletes performing long-distance sports and bodybuilding, because this amino acid is important for the muscle tissue recovery and for the muscle metabolism, while increasing exercise endurance.

Bodybuilders usually use Valine together with Isoleucine and Leucine to promote muscle growth and to supply them with an energy. Besides, this amino acid helps them recover tissues damaged during physical activity. Athletes commonly know that Valine is vital for the muscle metabolism and the growth of muscle tissue as it assists in maintaining the proper amount of nitrogen in the body.