Aspartic Acid

In 1868, Aspartic acid was isolated from legume in plant seeds and is apparently known as an amino acid obtained as a product of the hydrolysis of proteins.

Chemical Structure
Structure of Aspartic acid

IUPAC Name: (2S)-2-Aminobutanedioic acid
Symbol: Three-letter code - Asp. One-letter code - D
Molecular Weight (Molar Mass): 133.10268 g/mol
Molecular Formula (Structural Formula): C4H7NO4
Canonical SMILES: C(C(C(=O)O)N)C(=O)O
Isomeric SMILES: C([C@@H](C(=O)O)N)C(=O)O
InChIKey Identifier: CKLJMWTZIZZHCS-WHFJSZMODF
CAS Number: 56-84-8
MDL Number: MFCD00002616
Melting point: 270 °C
Solubility in water: 5,0 g/L (25 °C); pKa - 1,88; pKb - 9,60
2D Molfile: Get the molfile
3D PDB file: Get the PDB file
Other names: Aspartate; (S)-Aminobutanedioic acid; L-Aminosuccinic acid; Asparagic acid; L-Asparagic acid; Asparaginic acid; L-Asparaginic acid; Aspartic acid; (L)-Aspartic acid; (S)-Aspartic acid; H-Asp-OH


This amino acid is non-essential and widely distributed in proteins, though it is proved to play a major role in the energy cycle of your body. Besides, Aspartic acid also participates in the ornithine cycle, in transamination reactions, as well as in the formation of pyrimidines, purines, carnosine, and anserine. This amino acid is necessary for stamina, brain and neural health. Some time ago, Aspartic acid was found to be very important in the functioning of RNA and DNA, as well as in the production of immunoglobulin and antibody synthesis.

Aspartic acid is believed to help your body promote a robust metabolism. From time to time it is used to treat depression and fatigue. This amino acid plays a key role in the citric acid cycle (also known as Krebs cycle), within which a number of other amino acids and biochemicals are formed.

Basically, Aspartic acid got its reputation for being a treatment substance for chronic fatigue and for the vital role it plays in generating cellular energy. Moreover, this amino acid promotes a transportation of minerals to the cells, which are essential to form healthy RNA and DNA, while strengthening the immune system through stimulating an increased production of immunoglobulins and antibodies.

If you want your mind sharp, you will look for Aspartic acid, because it's responsible for keeping your mind in that state by increasing concentrations of NADH in the brain. This, in turn, is believed to boost up the production of chemicals necessary for proper mental functioning. Finally, this amino acid is recognized as an important element removing excess toxins from the cells, especially ammonia, that damages human liver, brain, and nervous system.

Aspartic acid is a non-essential amino acid, so your healthy body is able to produce its own supply. Besides, it can also be found in such food sources as dairy, beef, poultry, sugar cane and molasses. Individuals with diets low in protein or having eating disorders or malnutrition may suffer from the results of Aspartic acid deficiency like extreme fatigue or depression.